0557 GMT December 17, 2017
Sodium bicarbonate is used to combat buildup of acid in the blood, in open heart surgery, as an antidote to certain poisons, in cases of organ failure, and in some types of cancer chemotherapy, thestar.com wrote.
Officials with Alberta Health Services said the province had about a six-to-seven-week supply of injectable sodium bicarbonate when the manufacturer, Pfizer, told them on June 8 about a shortage.
Late this week, the company announced it was recalling two lots of vials of the drug due to the potential for microbial contamination, reducing the Alberta supply to just six to seven days.
The global supply of the vials has been tight since late May due to manufacturing delays and Health Canada said the recall means that there is now a shortage in Canada and around the world.
Health Canada said it is working closely with the company, the provinces and territories as well as other partners and stakeholders to reduce the impact of the shortage on Canadian patients.
“We are gathering information about the supply situation and possible mitigation strategies, including alternative sources,” it said in a release.
“Locating alternative supply may be challenging in an international shortage.”
There are two injectable sodium bicarbonate drugs authorized in Canada, both supplied by Pfizer — vial format and pre-filled syringes. The recall does not affect the pre-filled syringe format.
Hospira, the division of Pfizer that makes the drugs, said in a statement on Thursday that the contamination in sodium bicarbonate and several other products was discovered during a “routine simulation of the manufacturing process” which it said presented the potential for the introduction of microorganisms into the products.
It said that no batches of distributed product have been found to actually contain microorganisms, but that contamination remains a possibility.
An additional supply of the pre-filled syringes is expected in late July or early August.